에이아이클라우드 플랫폼

Peptide Filling

Requires Modeller: Filling uses homology modelling. Install Modeller with a free academic license from salilab.org.

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Template Sequence:

Model Sequence: Template sequence must be contained in model sequence

Mode:

Peptide Alone

Peptide in Complex (with protein)

About Filling

Add flanking amino acids to extend your peptide structure using homology modeling.

Example:

Template: AKAFIAWLVRG
Model: LKAKAFIAWLVRGKL

Adds L to N-terminus and KL to C-terminus

Peptide Capping

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Peptide Sequence:

Capping Options:

N-terminus — Add ACE (Acetyl group)

C-terminus — Add NME (N-methylamide)

About Capping

Protect peptide termini by adding capping groups.

Capping Groups:

ACE — Acetyl (N-term)
NME — N-methylamide (C-term)

Benefits:

Improved stability
Protease resistance
Mimic natural peptides

Peptide Mutation

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NNAA Source:

Use Pre-loaded Library

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Select NNAA:

Chain ID:

Position:

NNAA Chain:

NNAA 3-Letter Code:

About Mutation

Replace a natural amino acid with a non-natural analog.

Common Mutations:

Met → Nle — Oxidation resistance
Gly → Aib — Helix stabilization
Lys → Orn — Charge modulation

Available NNAAs:

AIB SAR NLE ORN NVA

Structure Modifications